nerve cells

How does changing electric charge on the two sides of a nerve cell plasma membrane during depolarization cause voltage-gated ion channel proteins to change shape?
1.

There is a change in attraction between charges in the protein and charges on either side of the membrane
2.

The sodium pump induces channel protein shape change
3.

Na+ ions that enter the cell bind to the channel proteins
4.

When K+ ions leave the cell they lose binding to the channel protein

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